Nuclear localization of influenza B polymerase proteins and their binary complexes
نویسندگان
چکیده
منابع مشابه
Immunofluorescent localization of the proteins of nuclear ribonucleoprotein complexes
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The influenza A genome consists of eight single-stranded RNA molecules, each associated with an oligomeric core of the structural protein, nucleoprotein, to form a distinct viral ribonucleoprotein (vRNP) complex. vRNPs are the entities responsible for the transcription and replication of the influenza viral RNAs in the nuclei of host cells. Thus, nuclear targeting and localization of the vRNPs ...
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Influenza virus nucleoprotein (NP) is a critical factor in the viral infectious cycle in switching influenza virus RNA synthesis from transcription mode to replication mode. In this study, we investigated the interaction of NP with the viral polymerase protein complex. Using coimmunoprecipitation with monospecific or monoclonal antibodies, we observed that NP interacted with the RNP-free polyme...
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ژورنال
عنوان ژورنال: Virus Research
سال: 2011
ISSN: 0168-1702
DOI: 10.1016/j.virusres.2010.12.017